SNPs rs1414493 in FH gene and rs11540478 in IDH2 gene were significantly associated with the decreased HCC overall recurrence risk under dominant (HR = 0.77, 95%CI 0.61–0.97, P = 0.030) and recessive (HR = 0.25, 95%CI 0.09–0.68, P = 0.007) models, respectively. This evidence concerns the gene IDH2 and hepatocellular carcinoma.