The baseline serum LAMP-2 was significantly higher in patients with PBC (884.26 ng/mL in average, ranged from 559.12-1126.87), than those in patients with HBV (386.45 ng/mL in average, ranged from 112.07-681.55, p<0.001), HCV (245.33 ng/mL in average, ranged from 96.89-385.46, p<0.001), IC (302.26 ng/mL in average, ranged from 25.56-561.35, p<0.001), and healthy controls (128.33 ng/mL in average, ranged from 37.92-207.00, p<0.001). This evidence concerns the gene LAMP2 and primary biliary cholangitis.