The findings show that APS reduces both IL-1β- and TNF-α-mediated mRNA expression of IL-6 and IL-8 and is also capable of attenuating IL-1β-mediated NF-κB activation suggested that this antioxidant may also suppress the secretion of IL-6 and IL-8 by SZ95 sebocytes. The gene discussed is NFKB1; the disease is autoimmune polyendocrinopathy.