INS and Hyperglycemia: The addition of octreotide prevented hyperglycemia-stimulated endogenous production of insulin except at the end of the 3-hours hyperglycemia when plasma insulin and C-peptide concentrations were modestly increased (insulin 6.45 ± 0.86 mU/l at baseline vs. 10.76 ± 2.1, p < 0.05, C-peptide 0.72 ± 0.06 mU/l at baseline vs. 1.08 ± 0.18, p < 0.05).