Since it was shown previously that HG treatment of monocytes in vitro increases expression of Toll-like receptors [21] and also monocytes from patients with type 2 diabetes show a higher expression of TLR2 and TLR4 compared to healthy subjects [15], we investigated the expression of these two receptors in circulating blood cells and SAAT in obese women. The gene discussed is TLR4; the disease is type 2 diabetes mellitus.