For example, the most recent ARB, azilsartan medoxomil, increased Ang (1–7) levels and reduced renal 20-hydroxyeicosatetraenoic (HETE) acid levels along with prevention of hypertension and target organ damage in Ang II-induced hypertension in Sprague-Dawley rats [101]. The gene discussed is ANG; the disease is Hypertension.