NUDT1 and neoplasm: A key finding from our study is that low MTH1 levels prevent expansion of cells with high RAS oncoprotein levels and associated ROS levels which mediate oncogenic signaling [27], the EMT phenotype [28] which generates highly metastatic tumors and influences maintenance of cancer stem cell populations [29, 30], and glycolytic adaptation which enables survival under hypoxic tumor growth conditions [31].