We investigated the effect of co-inherited HbAS and α+thalassemia on cytoadhesion of pRBCs infected with parasites of the ItG strain (which binds to both CD36 and ICAM1 (Baruch et al., 1996)) in a total of 99 RBC samples of various Hb and α+thalassemia genotype combinations. This evidence concerns the gene CD36 and alpha thalassemia spectrum.