Ex vivo treatment with cytotoxic T lymphocyte associated antigen-4 (CTLA-4) blocking antibodies of T-cell CD8+, isolated from patients affected by HCC, showed an expanded antigen-specific T-cell repertoire, alluding that ipilimumab and tremelimumab may possess a therapeutic potential in treating hepatocarcinoma [93]. Here, CD8A is linked to hepatocellular carcinoma.