Seven HCC-specific TAAs that are targeted by T cells have been identified: alpha-fetoprotein (AFP), glypican-3 (GPC3), NY-ESO-1, SSX-2, melanoma antigen gene-A (MAGE-A), telomerase reverse transcriptase (TERT) [27–31], hepatocellular carcinoma-associated antigen-519/targeting protein for Xklp-2 (HCA519/TPX2) [32]. This evidence concerns the gene AFP and hepatocellular carcinoma.