In our study, we examine the relationship between single nucleotide polymorphisms (SNPs) of APOE (rs449647), BDNF (rs2030324), GRIN2B (rs3764028), and HSP70-1 (rs1043618) genes and the possible occurrence risk of primary open angle glaucoma in the Polish population. This evidence concerns the gene GRIN2B and open-angle glaucoma.