Multivariate regression analysis showed that the most representative variables associated with CDKN2A mutation carriers were earlier age at diagnosis (OR 1.060; 95% CI 1.016–1.105), in situ melanomas (OR 6.961; 95% CI 1.895–25.567), the presence of multiple melanomas (OR 8.920; 95% CI 2.399–33.166) and immunopositivity of the tumours for cytoplasmic survivin (OR 9.072; 95% CI 1.025–85.010) (Table 7). This evidence concerns the gene CDKN2A and neoplasm.