The genes SCN1A, SCN2A coding for the alpha subunit have been linked to specific idiopathic epilepsy syndromes such as generalized epilepsy with febrile seizures plus (GEFS+) and benign familial neonatal-infantile seizures (BFNIS), respectively [17]. This evidence concerns the gene SCN2A and Benign familial neonatal-infantile seizures.