A case of a boy diagnosed with autism, no dysmorphic features, and a de novo balanced translocation 46, XY,t(7;16)(p22.1;p11.2) suggests that overexpression of gene RNF216 (localized to 7p22.1 by the Mammalian Gene Collection) resulting in abnormalities in E3 ubiquitin ligase may be linked to autism as well as other developmental and psychiatric conditions [9, 10]. The gene discussed is RNF216; the disease is autism.