CREBBP and Intellectual disability: Furthermore, microarray assays revealed a significant downexpression of the FSCN1 gene in CREB binding protein-depleted cells found in Rubinstein–Taybi syndrome that is characterized by intellectual disability and growth restriction, multiple congenital malformations such as broad thumbs and big toes, heart defects, cryptorchidism, and increased tumor risk [16]; some of these features are also present in 7p22 patients.