The expression of connective tissue growth factor (CTGF), cyclin-dependent kinase inhibitor 1C (CDKN1C), cytokine receptor EB13, transducer of ERBB-2 (TOB), and secreted apoptosis-related protein 3 (SARP3; sFRP5) genes was specifically upregulated in CHC cirrhosis, along with other apoptotic genes, such as Fas and TNF-α. The gene discussed is SFRP5; the disease is cryohydrocytosis.