Recent studies have demonstrated that KLF4 expression is decreased or lost in cancer and the inhibition of its expression induces EMT by regulating the expression of EMT-related genes, such as E-cadherin, N-cadherin, vimentin, β-catenin, vascular endothelial growth factor (VEGF)-A, endothelin-1 and Jnk1 in breast cancer (9) or through crosstalk with the TGF-β, Notch and Wnt signaling pathways in gastrointestinal cancer (10). This evidence concerns the gene VEGFA and breast cancer.