KIM‐1 is highly expressed postinjury to the kidney's proximal tubule and has been qualified as a biomarker of AKI in urine for preclinical investigations.18, 23 Recently, circulating KIM‐1 has been reported to be increased in rodent models of, and humans with, AKI and CKD, but not elevated in murine models of chemical‐induced liver injury.20 In mice, circulating KIM‐1 concentration tracks the increase in kidney expression, and in humans, plasma and urinary KIM‐1 are positively correlated. Here, HAVCR1 is linked to chronic kidney disease.