ANO5 and neuromuscular disease caused by qualitative or quantitative defects of dysferlin: In our cohort of patients, thirty-three are homozygous or compound heterozygous for causative mutations in ANO5. Interestingly only 18/33 are Italian (although they are 90% of the cohort), providing a further evidence of lower frequency of anoctaminopathies in this country [12] where dysferlinopathies and calpainopathies still remain the most common form of LGMD [28].