Distinctive features of LGMD2L versus other LGMD forms are: 1) the sex imbalance, with females that are less frequently or severely affected than males [10]; 2) asymmetry of muscle involvement that is rare among the LGMD and frequent in FSH [4]; 3) the pain following exercise that is typical of metabolic or inflammatory conditions [11]. Here, BRD2 is linked to limb-girdle muscular dystrophy.