Over-expression of VHL caused a 2- to 2.5-fold reduction in the expression of TPI1 under normoxic conditions in comparison to VHL-deficient RCC cells, while its expression was enhanced 2- to 3.9-fold under hypoxia in the VHL+ RCC cells when compared to normoxic conditions (Figure 3C). The gene discussed is TPI1; the disease is renal cell carcinoma.