Moreover, among the discussed studies, different types of molecular evidence were considered as the sign of AD-like amyloid pathology, including Aβ plaque-like structures in STZ-induced model [96], APP containing plaques in PolyI:C-induced model [5], increased levels of alpha-, beta-, and gamma-secretase activity in brain lysate, and intracellular Aβ aggregates in LPS model [50]. Here, APP is linked to Alzheimer disease.