TNFAIP3 and systemic lupus erythematosus: Furthermore, TNFAIP3 rs2230926 polymorphism has been demonstrated to be significantly associated with systemic lupus erythematosus (SLE) among multiple ethnic populations [21,24-29] and other autoimmune diseases such as Sjögren’s syndrome, Crohn’s disease, psoriasis and rheumatoid arthritis [30,31].