Microglial cells become rapidly activated in response to infection, inflammation, or injury, and their activation is associated with the production and secretion of a variety of compounds such as cytotoxic molecules, including reactive oxygen species (ROS), nitric oxide (NO) and prostaglandin E2 (PGE2), and a variety of proinflammatory cytokines, including interleukin Il-1β, Il-6, and tumor necrosis factor alpha (Tnf-α) [2]. This evidence concerns the gene TNF and infection.