IRF1 and demyelinating disease of central nervous system: Indeed, Irf1 and Irf7 are important regulatory factors in the development of demyelination diseases of the CNS, such as MS and experimental autoimmune encephalomyelitis (EAE) [54,55], whereas Irf9 and Irf1 are important in injury-induced type 1 IRF signaling, which regulates inflammatory responses in the CNS [56].