In order to study molecular pathways relevant to androgen deficiency, we focused on cytochrome P450 17A1 and cytochrome b5 type A. In the two published RA genome-wide association study (GWAS) datasets, we reanalyzed single nucleotide polymorphisms (SNP) in the CYB5A gene [31,32]. The gene discussed is CYB5A; the disease is rheumatoid arthritis.