Although the TWEAK/Fn14 interaction contributes to pro-inflammatory effects and tissue remodeling [15,16] and high TWEAK expression was observed in the skin of patients with atopic dermatitis as compared with healthy subjects [17], the exact mechanisms that underlie TWEAK-mediated airway remodeling have not been elucidated. This evidence concerns the gene TNFSF12 and atopic eczema.