TGFB1 and melanoma: Functional enrichment analysis of up-regulators using the IPA tool revealed that TGFB1 (p = 8.89 × 10−32) and MITF (p = 1.51 × 10−21) were again significantly and consistently enriched, suggesting that gain-of-function in BRAFV600E may generally influence the down-stream genes mediated by those two genes or pathways in different developmental stages of melanoma.