According to the effects of putative BRAFV600E targets on melanoma cell proliferation, we identified top tumor suppressor genes including TGFB1, TGFB1I1, PRODH, NAT6, ZNF205, ZNF142, FRS3, RUNX3, IGFBP5, HPGD, MAPK11, and NFIC, which significantly increased cell growth and proliferations. The gene discussed is ZNF205; the disease is melanoma.