In conclusion, this study confirmed five previous reported SLE susceptibility loci in Han Chinese population, such as TNFSF4, IRF8, miR-146a, CD44 and TMEM39A. These findings not only provide novel insights into the genetic architecture of SLE but also might highlight the contribution of multiple variants of modest effect. The gene discussed is TMEM39A; the disease is systemic lupus erythematosus.