In the present study, six SNPs in five known SLE susceptibility loci showed evidence of highly significant association evidence in combined analysis: TNFSF4 (rs1418190, rs4916219), IRF8 (rs2934498), miR-146a (rs2431697), CD44 (rs2732547), and TMEM39A (rs12494314). This evidence concerns the gene IRF8 and systemic lupus erythematosus.