When the genotypic data from the GWAS and the replication 1 were combined, we identified two SLE susceptibility genes reaching genome-wide levels of significance (Pmeta = 5.00 × 10−08): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, Pmeta = 1.08 × 10−08; rs4916219, OR = 0.80, Pmeta = 7.77 × 10−09), and IRF8 (rs2934498, OR = 1.25, Pmeta = 4.97 × 10−9) and another 12 SNPs also showed evidence suggestive of association (Table 2). Here, IRF8 is linked to systemic lupus erythematosus.