TMEM39A and systemic lupus erythematosus: When we combined the genotypic data from the GWAS and two independent replication cohorts, an additional three SNPs within three known SLE susceptibility loci reach genome-wide levels of significance: miR-146a (rs2431697, OR = 0.69, Pmeta = 1.15 × 10−22), CD44 (rs2732547, OR = 0.82, Pmeta = 1.55 × 10−11), and TMEM39A (rs12494314, OR = 0.84, Pmeta = 1.01 × 10−09) (Table 2).