In the present study, we identified a new SNP rs2934498 near rs2280381 (D’ = 0.325, r2 = 0.008) and rs11644034 (D’ = 0.984, r2 = 0.049), indicating that IRF8 is also susceptible to SLE in the Chinese population. This evidence concerns the gene IRF8 and systemic lupus erythematosus.