To understand the clinical significance of Sp1 and c-Myc, paired CD34+ and CD34- cells from 56 AML patients were analyzed, and relative mRNA levels were determined as shown in Figure 7A. Both Sp1 and c-Myc were substantially up-regulated in CD34+ AML samples compared with their differentiated counterparts. This evidence concerns the gene SP1 and acute myeloid leukemia.