CD4 and neoplasm: Experimental T cell elimination remarkably reduced the therapeutic efficacy of radiation in a mouse model [23], and we have previously demonstrated that the densities of CD4(+) and CD8(+) tumor-infiltrating lymphocytes (TIL) were significantly associated with the histological grade after CRT, and the density of CD8(+) TIL was an independent prognostic factor for achieving CR after CRT [19].