Urine samples from patients with high disease activity (SLEDAI ≥10) and recent biopsy-proven LN (n = 14) or high renal disease activity (SLEDAI ≥10 and renal SLEDAI ≥8, n = 5) had high numbers of both CD4+ (median 1,415 cells/dl urine) and CD8+ T cells (median 1,911 cells/dl urine). The gene discussed is CD8A; the disease is kidney disorder.