Given that several monoclonal human aPL inhibit the inactivation of procoagulant SP and functional activities of anticoagulant/fibrinolytic SP [7,9,12,13], it has been suggested that some aPL may recognise the catalytic domain of SP, leading to dysregulation of haemostasis and vascular thrombosis in APS. Here, FASLG is linked to autoimmune polyendocrinopathy.