For example, ApoE2 has poor affinity to the hepatic lipoprotein receptor, resulting in decreased catabolism of triglyceride-rich lipoproteins and accumulation of VLDL and chylomicron remnants in the blood [13], whereas ApoE4 is associated with the increased clearance of these lipoproteins, resulting in hypercholesterolemia and elevated levels of LDL [6]. The gene discussed is APOE; the disease is familial hypercholesterolemia.