Patients with primary hepatic SCC and ASC shared the similar performance of common serum tumor biomarkers, like negative level of AFP (≤10 ng/ml), and a part of positive level of CA 19-9 (>37 U/ml) that may distinguish them from most hepatocellular carcinoma and part of metastatic liver tumor, but it was incapable of picking them out from other kinds of metastatic liver tumor and most of usual intrahepatic cholangiocarcinoma. Here, AFP is linked to hepatocellular carcinoma.