Considering that RBM10v1(V354) expression correlated with preferential NUMB exon 11 exclusion and RBM10v1(V354E) expression correlated with preferential NUMB exon 11 inclusion [2] and that expression of the exon 11 retaining NUMB transcript is frequently increased in lung adenocarcinomas [19], one might predict that (a) downregulation of RBM10v1(V354) is one means by which lung cancer cells circumvent proliferation controls, and (b) more RBM10v1(V354del) than RBM10v1(V354) is expressed in lung cancers. This evidence concerns the gene NUMB and lung cancer.