The ITLN1 immunoreactivity was significantly higher in NB cases with age less than 1 year (P = 0.03), good differentiation (P < 0.001), lower mitosis karyorrhexis index (MKI) (P = 0.002), and early INSS stages (P = 0.003) (Additional file 7: Table S1). The gene discussed is ITLN1; the disease is neuroblastoma.