Since cell surface GRP78 forms complex with PI3K to promote the production of phosphatidyl inositol-3,4,5-triphosphate (PIP3) and subsequent PI3K/AKT signaling [40], we suspect that ITLN1 may modulate the PI3K/AKT signaling through interacting with GRP78 and regulating its activity in NB cells, which warrants our further investigation. The gene discussed is HSPA5; the disease is neuroblastoma.