For example, Zhang et al. demonstrated that lncRNA SPRY4-IT1 (SPRY4 intronic transcript 1) was increased in clear cell renal cell carcinoma (ccRCC) tissues and ccRCC patients with higher SPRY4-IT1 expression had an advanced clinical stage and poorer prognosis [22]. The gene discussed is SPRY4; the disease is nonpapillary renal cell carcinoma.