PSVue 794 has a low molecular weight, so it can distribute through the circulation with less hindrance than the larger annexin V. Although a direct comparison between the two molecules has yet to be demonstrated in the current arthritis model, the NIR dye has been shown to label human epidermoid carcinoma xenografts with broken blood vessels more efficiently than annexin V [27,32]. This evidence concerns the gene ANXA5 and Arthritis.