CD38 and chronic myelogenous leukemia, BCR-ABL1 positive: In CML, chronic phase occurs after BCR-ABL1 oncogene expression in hematopoietic stem cells (HSCs), that can then generate an expansion of a pool of myeloid GMP (CD34 + CD38 + Lin−) progenitors that aberrantly acquire the capacity to self-renew, leading to progenitor LSC generation and BC transformation [2].