CD4 and anemia: However, the strongest independent predictor of mortality was time-updated severe anaemia (adjusted IRR = 8.0 [95%CI, 3.9-16.4]), while time-updated moderate anaemia (adjusted IRR = 6.0 [95%CI, 3.9-9.2]) and CD4 counts <100 cells/uL (adjusted IRR = 6.5 [95%CI, 2.8-15.0]) were also very strong independent predictors.