As we show in this study that IL-12, IL-18 and their combination do not have any significant in vitro effect on DNAM-1 expression on NK cells and their subsets in HC, as well as in MM patients it is possible that DNAM-1 receptor expression on NK cells is not only the cytokine but also experimental conditions-dependent that is in accord with a few data in literature [34,35]. Here, IL18 is linked to Miyoshi myopathy.