Analyzing the modulation of DAP10, NKG2D adaptor molecule, after 18 h cytokine treatments of PBMC in HC, as well as in MM patients, we show that IL-18 alone high significantly (p < 0.01, exact Wilcoxon signed rank test) decreases mRNA level of this signaling molecule only in MM patients (Figure 4b). This evidence concerns the gene IL18 and Miyoshi myopathy.