We, therefore, consider that it is of interest to assess in vitro effects of IL-12, IL-18 and their combination on NK cell effector functions, cytotoxicity and IFN-γ production, as well as on the expression of numerous receptors on NK cells and their dim and bright subsets in metastatic melanoma (MM) patients and healthy controls (HC). The gene discussed is IL18; the disease is metastatic melanoma.