Our results also indicate that in both HC and MM patients IL-12 alone or in combination with IL-18 significantly (p < 0.05, Wilcoxon signed rank test) or high significantly (p < 0.01, Wilcoxon signed rank test) increases the percentage or MFI of CD107a degranulation marker on NK cells and both their dim and bright subsets. This evidence concerns the gene LAMP1 and Miyoshi myopathy.