IL18 and Miyoshi myopathy: Furthermore, MM patients that have distant metastasis in liver have significantly (p < 0.05, Mann–Whitney exact test) or high significantly (p < 0.01, Mann–Whitney exact test) lower enhancement in NK cell cytotoxicity after in vitro treatment with IL-12 alone or in combination with IL-18 compared to the increase in NK cell cytotoxicity in MM patients with distant metastases in skin, subcutaneous layer and lymph nodes.