The clinical characteristics of the RA patients are as follows: 17 females and 3 males, age 57.5 ± 3.7 years (range: 26 to 87 years), disease duration 3.5 ± 0.7 years (range: 0.1 to 12 years), ESR 51.1 ± 7.1 mm/h (range: 8 to 116 mm/h, normal <15), serum CRP 2.7 ± 0.3 mg/dL (range: 0.5 to 5.6 mg/dL, normal <0.3), SF CRP 1.9 ± 0.2 mg/dL (range: 0.5 to 4.7 mg/dL), rheumatoid factor 70.9 ± 16.9 IU/mL (range: 3 to 266 IU/mL, normal <18) and anti-cyclic citrullinated protein antibody 64.1 ± 23.6 U/mL (range: 0.3 to 338 U/mL, normal <5). This evidence concerns the gene CRP and rheumatoid arthritis.