A systematic review of 48 studies describing malaria diagnostic performance that accounted for the imperfect reference standard indicated that although performance varied by species, parasite density and immunity, overall HRP2-detecting RDTs outperformed pLDH-based RDTs and microscopy with high sensitivity and specificity for diagnosing malaria in clinical cases in endemic settings, and also asymptomatic malaria infections in endemic areas [2]. The gene discussed is HDGFL2; the disease is malaria.