HDGFL2 and infection: Some studies compare HRP2-detecting RDTs to polymerase chain reaction (PCR) and/or microscopy results to distinguish between persistent antigenaemia, and acute infection; and alternatively, it has been suggested that because pLDH is metabolized after three to five days following anti-malarial therapy, that pan-pLDH test bands on combination RDTs could be used to distinguish between persistent antigenaemia (following treatment), and active infection [6].