Although no association between class I HLA (HLA-A, HLA-B, and HLA-C) genes and HSP was found by Ostergaard et al. [10], HLA-B*35 allele has been suggested to be a potential marker of renal complications secondary to HSP by Nathwani et al., Nyulassy et al. and Amoli et al. [7-9]. The gene discussed is HLA-C; the disease is hereditary spastic paraplegia.