Interestingly, and as shown in Table 3, the association of HLA-B*41:02 with HSP susceptibility remained statistically significant irrespective of HLA-DRB1*01:03 (P = 0.0004, OR = 4.97 (1.8 to 16.9)) (Table 3). The gene discussed is HLA-B; the disease is hereditary spastic paraplegia.