HLA-B and hereditary spastic paraplegia: This association was mainly due to the HLA-B*41:02 allele (8.3% in HSP patients versus 1.5% in controls; P = 0.0001; OR = 5.76 (2.15 to 19.3)) and remained statistically significant after adjusting for Bonferroni correction (P = 0.0028) (Table 2).