A set of seven CpG island-containing promoters (BIRC5, CDC25C, CLU, GSTP1, NRG1, RASSF1, SOCS1) was investigated on the panel of TP53 wild-type codon 72 Arg or Pro HCC cell lines (Additional file 3: Figure S2). This evidence concerns the gene SOCS1 and hepatocellular carcinoma.