ITGAX and Langerhans cell histiocytosis: Berres et al. [102] reported that patients with LCH-RO (+) carried the BRAF V600E mutation in circulating CD11c + and CD14+ cellular fractions as well as in BM CD34+ hematopoietic cell progenitors, whereas the mutation was restricted to lesional LCH cells in patients with LCH-RO (−).