In the present situation, adjuvant chemotherapy is conducted for patients categorized into a high-risk group among those with stage II disease on the basis of various histopathological or clinical parameters such as poorly differentiated histology, lymphovascular invasion, perineural invasion, T4 tumor stage, bowel obstruction or perforation, and an elevated preoperative plasma level of carcinoembryonic antigen (CEA) [7]. Here, CEACAM5 is linked to neoplasm.