Hamerlik et al showed that VEGF-VEGFR2-NP1-mediated signaling in glioma stem-like cells is maintained in an autocrine manner through the continuous secretion of VEGF, thereby allowing constitutive activation of downstream pro-survival pathways and growth of glioblastomas, tumor invasion and increased resistance to treatment [26]. The gene discussed is VEGFA; the disease is glioblastoma.