As we currently know, Neuropilins are unable to form homodimers, and as such, must mediate their effects through heterodimeric interactions with other receptors such as KDR or Plexins, highlighting NP1, or NP2, as critical elements involved in mediating VEGF signaling and supporting cell survival in NSCLC. This evidence concerns the gene VEGFA and non-small cell lung carcinoma.