Moreover, albuminuria has been viewed as a mirror of microvascular dysfunction, which results in vascular leaking of not only albumin, collagen and cholesterol, but also advanced glycation end products, and is the primary mediator of myocardial fibrosis due to the suppression of collagen turnover via impaired crosslinking of collagen [29,36]. The gene discussed is ALB; the disease is Myocardial fibrosis.