To investigate whether lentiviral-ADAR1 expression alters RNA editing and can be detected by RESSq-PCR at CSC-associated sites in primary hematopoietic stem and progenitor cells, CD34+ cells were isolated from healthy human bone marrow (BM) or peripheral blood samples from CP CML patients. This evidence concerns the gene ADAR and chronic myelogenous leukemia, BCR-ABL1 positive.