These results are consistent with the similar frequencies observed in cases (0.388 and 0.391) and controls (0.126 and 0.121, respectively) but with the low LD between these variants in Iranian (r2 = 0.58), and support the notion that rs76546355/rs116799036 and HLA-B*51 are independent genetic risk factors for BD in Iranians. This evidence concerns the gene HLA-B and Behcet disease.