To confirm the previously described associations with BD of polymorphisms in the MHC locus and to compare them with the HLA-B*51 association in an Iranian sample, we selected the top four MHC SNPs identified in GWAS conducted on Japanese, Chinese and Turkish samples (rs4959053 from Mizuki et al. [19] and Hou et al. [5], rs9260997 and rs2848713 from Remmers et al. [4], and rs4947296 from Lee et al. [6]) and the top SNP (rs116799036, currently known as rs76546355) identified on a recent and exhaustive study of the MHC locus in Italian and Turkish BD cases and controls [7]. This evidence concerns the gene HLA-B and Behcet disease.