ANGPTL2 and coronary stenosis: More recently, Horio et al. demonstrated that ANGPTL2 was abundantly expressed in atheromatous plaques in human coronary artery, and that the circulating ANGPTL2 levels measured by ELISA were higher in human subjects with CHD (defined by coronary artery stenosis ≥75% on coronary angiography; n = 89) compared with age-matched non-CHD subjects (n = 30) [9].