Furthermore, they showed that serum ANGPTL2 levels were associated with carotid IMT in 359 seniors aged between 85 to 99 years with no history of CVD, but with relatively reduced eGFR (mean 62.5 ± 16.8 ml/min/1.73m2) and advanced stages of atherosclerosis (mean carotid IMT of 0.99 ± 0.15 mm compared with our current study measurement of 0.69 ± 0.12 mm), among whom a small proportion of subjects with diabetes was included (approximately 18.4%) [9]. This evidence concerns the gene ANGPTL2 and atherosclerosis.