In addition to the SLC2A9-SSB interaction discussed previously [26], there is non-additive interaction between alcohol exposure and the lipoprotein receptor-related protein 2 gene (LRP2) (rs2544390) in the risk of gout in Polynesian populations, where the protective effect of the T-positive genotype is negated by exposure to alcohol [53]. The gene discussed is SLC2A9; the disease is gout.