Comparing the MTLE groups, we found in specific hippocampal subfields an increased immunoreactive area of GFAP and HLA-DR and decreased MT-I/II and AQP4 in specimens from the MTLE patients with psychosis; while in specimens from patients with MTLE and major depression, GFAP and MT-I/II were decreased. The gene discussed is AQP4; the disease is major depressive disorder.